Journal of Nutraceuticals and Health

ABSTRACT

Parkinsons disease (PD) is one of the most common neurodegenerative diseases, which comes in second place in terms of prevalence after Alzheimers disease. The rate of incidence of PD increases with the advancement of age. Searching for nutraceuticals for the management of PD is a good approach since, so far, there is no efficient drug for such a disease. In addition, an interrelation of the immune system and iron status in PD is an important issue to be studied. In this context, a question arises: do the nutraceuticals that can improve the disease may also enhance the iron status?

The research entitled "Iron status, immune system, and expression of brain divalent metal transporter 1 and dopamine receptors D1 interrelationship in Parkinsons disease and the role of grape seed and green coffee bean extracts and quercetin in mitigating the disease in rats newly published in the Journal of Herbmed Pharmacology studied the role of nutraceuticals represented by the flavonoid quercetin and the ethanol extracts of either green coffee bean or grape seed in prevention of PD in rats [1]. The research focused on the effects of nutraceuticals on iron status and the immune system and the proposed mechanisms for PD management. The expression of brain dopamine receptors D1 (DRD 1) and divalent metal transporter 1 (DMT 1) are among the mechanisms that have been studied. The study also followed the histopathological brain changes to confirm the biochemical and molecular changes.

KEYWORDS

1. Parkinson’s disease
2. Neurodegenerative diseases
3. Antioxidants
4. Immune system
5. Iron status
6. Dietary supplements